Identification of SUMO modification sites in the base excision repair protein, Ntg1
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- 作者：Daniel B. Swartzlandera ; b ; 1 ; 2 ; Annie J. McPhersona ; b ; 2 ; Harry R. Powersa ; 3 ; Kristin L. Limposea ; c ; Emily G. Kuipera ; d ; Natalya P. Degtyarevaa ; e ; Anita H. Corbetta ; e ; acorbe2@emory.edu" class="auth_mail" title="E-mail the corresponding author ; Paul W. Doetscha ; e ; f ; g ; medpwd@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Base excision repair (BER) ; Ntg1 ; NTHL1 ; SUMO ; Sumoylation
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：51-62
- 全文大小：3167 K
文摘
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Base excision repair (BER) proteins can be modified by SUMO.
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Both S. cerevisiae Ntg1 and human NTHL1 can be sumoylated.
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Five lysines are identified as the sites of SUMO modification in Ntg1.
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An Ntg1 variant that cannot be modified by SUMO is generated.
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Cells where Ntg1 cannot be modified by SUMO fail to respond properly to DNA damage.