Local administration of resveratrol inhibits excitability of nociceptive wide-dynamic range neurons in rat trigeminal spinal nucleus caudalis
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- 作者：Yoshihito Shimazua ; Eri Shibuyaa ; Shiori Takehanaa ; Kenta Sekiguchia ; Katsuo Oshimab ; Hiroaki Kamatac ; Hiroyuki Karibec ; Mamoru Takedaa ; m-takeda@azabu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：SpVc ; trigeminal spinal nucleus caudalis ; WDR ; wide dynamic range ; CAM ; complementary and alternative medicine ; TRP ; transient receptor potential ; TRPA1 ; TRP ankyrin 1 ; DRG ; dorsal root ganglion ; ANOVA ; analysis of variance ; TTX-S ; tetrodotoxin sensitive ; TTX-R ; tetrodotoxin resistant
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：262-268
- 全文大小：1411 K
文摘
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Local resveratrol injection suppresses nociceptive SpVc WDR neuronal excitability.
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Neuronal firing rates were dose-dependently inhibited by resveratrol.
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The inhibitory effect of resveratrol lasted for 20 min and was reversible.
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The potency of inhibition by resveratrol almost equaled that of 1% lidocaine.
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Resveratrol may be an effective treatment option for trigeminal pain.