Postnatal development changes in excitatory synaptic activity in the rat locus coeruleus neurons
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- 作者：Masoumeh Kourosh Aramia ; b ; Sohrab Hajizadeha ; Saeed Semnaniana ; ssemnan@modares.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Locus coeruleus ; AMPA EPSCs ; NMDA EPSCs ; Postnatal development
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：365-371
- 全文大小：587 K
文摘
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A feature of synaptic maturation is an activity-dependent switch in the NMDA EPSC decay from slow to fast.
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Glutamatergic synapses show NMDA receptor activity from the first postnatal week.
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The kinetics of AMPA receptors matures early, whereas developmental changes in NMDA receptor kinetics proceed more gradually.
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Rise time kinetics of NMDA-mediated currents appears to mature earlier than decay kinetics.