Recent advances in mathematical modeling and statistical analysis of exocytosis in endocrine cells

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• 作者：Morten Gram Pedersen ; ^a ; ^{pedersen@dei.unipd.it} ; Alessia Tagliavini^a ; Giuliana Cortese^b ; Michela Riz^a ; ^c ; Francesco Montefusco^a
• 关键词：Hormone secretion ; Ca2+2+ microdomains ; Spatiotemporal Ca2+2+ dynamics ; Mixed-effects modeling ; Survival analysis ; α-cells ; β-cells ; Pituitary cells ; Secretory granules ; Large dense-core vesicles
• 刊名：Mathematical Biosciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：283
• 期：Complete
• 页码：60-70
• 全文大小：1355 K
• 卷排序：283

文摘

Hormones are released from endocrine cells as a result of granule exocytosis. We review recent quantitative methods for investigations of exocytosis. Discrete Ca2+ microdomains are important for exocytosis. Simulations of buffered Ca2+ diffusion provide insight into the dynamics of local Ca2+. Statistical time-to-event analysis can provide single-granule estimates of exocytosis rates. Applications to several endocrine cell types are provided.