Analysis of positions and substituents on genotoxicity of fluoroquinolones with quantitative structure-activity relationship and 3D Pharmacophore model

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• 作者：Chen Fengxian ; Hai Reti ; ^{hairetibeihua@outlook.com}
• 关键词：Fluoroquinolones ; Genotoxicity ; Quantitative structure-activity relationship ; Full factorial experimental design ; Pharmacophore model
• 刊名：Ecotoxicology and Environmental Safety
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：136
• 期：Complete
• 页码：111-118
• 全文大小：938 K
• 卷排序：136

文摘

Full factorial experimental design was applied in substituent characteristics of fluoroquinolones. Genotoxicity of FQs is regulated by the main effect and second-order interaction effect of positions and substituents. The modified FQ presents significant improvement in genotoxicity and efficacy.