Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity
详细信息 查看全文
- 作者：Min Zhanga ; Xiao-Li Lia ; Heng Lia ; Shan Wanga ; Cong-Cong Wanga ; Long-Tao Yueb ; Hua Xuc ; Peng Zhanga ; Hui Chena ; Bing Yanga ; Rui-Sheng Duana ; ruisheng_duan@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：A2AR ; A2A receptor ; EAN ; experimental autoimmune neuritis ; Treg ; regulatory T cell ; Tfh ; T follicular helper cell ; Teff ; effector T cell ; GBS ; Guillain&ndash ; Barré ; syndrome ; PNS ; peripheral nervous system ; CNS ; central nervous system ; EAE ; experimental autoimmune encephalomyelitis ; BPM ; bovine peripheral myelin ; MNCs ; mononuclear cells ; AIDP ; acute inflammatory demyelinating polyneuropathy ; AMAN ; acute motor axonal neuropathy ; i.p. ; intraperitoneally ; p.i. ; post-immunization ; CFSE ; carbox
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：293
- 期：Complete
- 页码：129-136
- 全文大小：1606 K
文摘
- •
The A2A receptor agonist, CGS21680, exacerbated experimental autoimmune neuritis.
- •
CGS21680 inhibited lymphocyte proliferation and IL-2 secretion.
- •
CGS21680 decreased Treg cells, while it increased Tfh cells, B cells and autoantibodies.
- •
The enhanced humoral immunity induced by CGS21680 possibly related to IL-2 deficiency.