Chronic inflammatory demyelinating polyradiculoneuropathy: A new animal model for new therapeutic targets
详细信息 查看全文
- 作者：J. de Sè ; ze ; jerome.de.seze@chru-strasbourg.fr ; L. Kremer ; C. Alves do Rego ; O. Taleb ; D. Lam ; W. Beiano ; G. Mensah-Nyagan ; E. Trifilieff ; S. Brun
- 关键词：CIDP ; Animal models ; Treatment ; Autoimmune
- 刊名：Revue Neurologique
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：172
- 期：12
- 页码：767-769
- 全文大小：273 K
- 卷排序：172
文摘
Animal models are fundamental to advance knowledge of disease pathogenesis and to test/develop new therapeutic strategies. Most of the current knowledge about the pathogenic mechanisms underpinning autoimmune demyelination processes implicating autoantigens has been obtained using the Experimental Autoimmune Neuritis (EAN) animal model. The most widely used EAN model is obtained by active immunization of Lewis rats using a peptide, P0 (180–199), issuing from the major peripheral nervous system myelin protein. But this model mimics only the classical monophasic acute form of demyelinating polyradiculoneuropathy, i.e. Guillain-Barré syndrome (GBS). We developed a new model by immunizing Lewis rats using the same immunodominant neuritogenic peptide P0 (180–199) but this time with its S-palmitoyl derivative, S-palm P0 (180–199). All of the animals immunized with the S-palm P0 (180–199) peptide developed a chronic relapsing-remitting form of the disease corresponding to the electrophysiological criteria of demyelination (slow sensory nerve conduction velocity, prolonged motor nerve latency, partial motor nerve conduction blocks) with axon degeneration. These findings were confirmed by immunohistopathology study and thus, appear to mimic human chronic inflammatory demyelinating polyradiculopathy (CIDP). This new model opens up new avenues of research for testing new anti-inflammatory and neuroprotective therapeutic strategies.