The HFE genotype and a formulated diet controlling for iron status attenuate experimental cerebral malaria in mice
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- 作者：Dominique F. Leitnera ; José ; A. Stouteb ; Mary Landmesserb ; Elizabeth Neelya ; James R. Connora ; jconnor@hmc.psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Malaria ; Iron ; Myelin ; Sema4A ; Epo ; IL-6
- 刊名：International Journal for Parasitology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：45
- 期：12
- 页码：797-808
- 全文大小：2278 K
文摘
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Iron status does not predict survival in experimental cerebral malaria.
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A common mutation in the HFE gene alters iron status but does not increase morbidity.
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A diet has been identified that provides adequate iron without increasing morbidity.
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Elevated Sema4A in brain of mice is associated with loss of myelin basic protein.