Transcutaneous carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD
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- 作者：Vasileios Andrianopoulos ; PhDa ; b ; VAndrianopoulos@schoen-kliniken.de" class="auth_mail" title="E-mail the corresponding author ; Lowie E.G.W Vanfleterena ; c ; lowievanfleteren@ciro-horn.nl" class="auth_mail" title="E-mail the corresponding author ; Inga Jaroschb ; IJarosch@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author ; Rainer Gloecklb ; d ; RGloeckl@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author ; Tessa Schneebergerb ; e ; TSchneeberger@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author ; Emiel F.M. Woutersa ; c ; ewouters@ciro-horn.nl" class="auth_mail" title="E-mail the corresponding author ; Martijn A. Spruita ; f ; martijnspruit@ciro-horn.nl" class="auth_mail" title="E-mail the corresponding author ; Klaus Kennb ; e ; KKenn@Schoen-Kliniken.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bf ; breathing frequency ; BMI ; body mass index ; BGA ; blood gas analysis ; CBG ; capillary blood gas ; COPD ; chronic obstructive pulmonary disease ; CRQ ; chronic respiratory disease questionnaire ; DLCO ; carbon monoxide diffusing capacity ; EID ; exercise-induced oxygen desaturation ; EIH ; exercise-induced hypercapnia ; FEV1 ; forced expiratory volume in 1&thinsp ; second ; HADS ; hospital anxiety and depression scale ; LTOT ; long-term oxygen therapy ; VE ; expired ventilation ; PCCO2 ; capillary carbon-dioxide part
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：233
- 期：Complete
- 页码：52-59
- 全文大小：976 K
文摘
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TCPCO2 response to 6MWT is highly heterogeneous in patients with advanced COPD.
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10">CO2 retention (TCPCO2 increase of >4 mmHg) is related to worse airflow limitation (FEV1) and higher pre-walk dyspnea.
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15">EIH (TCPCO2 levels of >46 mmHg at exertion) during the 6MWT is associated with higher baseline-PCCO2 values (≥41 mmHg) and higher pre-walk dyspnea.
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Overweight/Obese BMI seems to carry a protective effect against EIH in very severe COPD.
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Monitoring of TCPCO2 during 6MWT might help to identify patients who need special attention regarding to EIH.