Chronic diclofenac exposure affects gill integrity and pituitary gene expression and displays estrogenic activity in nile tilapia (Oreochromis niloticus)
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- 作者：Frederike Grö ; nera ; frederike.groener@igb-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Christin Hö ; hnea ; Wibke Kleinera ; Werner Kloasa ; b
- 关键词：Pharmaceutical ; Low-dose exposure ; Fish ; Gill histopathology ; Gonadotropins ; Vitellogenin
- 刊名：Chemosphere
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：166
- 期：Complete
- 页码：473-481
- 全文大小：973 K
文摘
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Hatching and survival were not affected by diclofenac exposure in O. niloticus.
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Mild to moderate histopathological alterations of gills occurred.
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Altered gonadotropin and vitellogenin gene expression patterns were found.
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Diclofenac possess an estrogenic endocrine activity at low concentrations.
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Detoxification enzymes were induced due to diclofenac exposure.