The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells
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- 作者：C.T.D. Kwoka ; M.H. Leunga ; J. Qina ; d ; Y. Qina ; J. Wangc ; Y.L. Leeb ; cherielee@hku.hk" class="auth_mail" title="E-mail the corresponding author ; K.-M. Yaoa ; kmyao@hku.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：hESCs ; human embryonic stem cells ; ES cells ; embryonic stem cells ; CDK ; cyclin-dependent kinases ; EC cells ; embryonal carcinoma cells ; EB ; embryoid bodies ; PI ; propidium iodide ; ROS ; reactive oxygen species ; GO ; gene ontology ; RPE ; retinal pigment epithelium ; RA ; retinoic acid ; bFGF ; basic fibroblast growth factor 2 ; CM ; conditioned medium ; DE ; definitive endoderm ; AVBF medium ; medium based on Stemline II Hematopoietic Stem Cell expansion medium supplemented with BMP4 ; hFF ; human foreskin fibrob
- 刊名：Stem Cell Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：16
- 期：3
- 页码：651-661
- 全文大小：1513 K
文摘
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FOXM1 is expressed in undifferentiated hESCs with peak levels at G2/M phase.
FOXM1 depletion causes mitotic defect and delays G2/M progression in hESCs.
FOXM1 downregulation does not induce rapid exit of undifferentiated state in hESCs.
FOXM1 depletion sensitizes hESCs to oxidative stress.
Genomic binding profile of FOXM1 in hESCs differs substantially from cancer cells.