Farletuzumab in lung cancer

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• 作者：Anish Thomas^a ; Julia Maltzman^b ; Raffit Hassan^c ; ^{hassanr@mail.nih.gov}
• 关键词：Adenocarcinoma ; Farletuzumab ; Folate receptor ¦Á ; Monoclonal antibody ; Non-small cell lung cancer ; Immunohistochemistry
• 刊名：Lung Cancer
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：80
• 期：1
• 页码：15-18
• 全文大小：304 K

文摘

Folate is essential for proliferating cells and folate transport pathways and folate-dependent metabolic processes show promise as targets for anti-neoplastic therapy. Folate receptor ¦Á (FOLR1), a folate transporter, is an attractive target for anti-neoplastic therapy due to its high affinity for folate, restricted range of expression in normal tissue and differential over-expression in malignant tissue. FOLR1 is expressed in non-small cell lung cancer, with a higher expression in adenocarcinoma compared with squamous cell carcinoma. Farletuzumab is a monoclonal antibody targeting FOLR1 which in pre-clinical studies led to cytotoxicity of FOLR1-expressing cells, inhibited tumor growth in animal models and showed limited reactivity with normal tissue. In phase I/II trials, farletuzumab was well tolerated as a single-agent and in combination, without additive toxicity with chemotherapy. An ongoing phase II, double blind, placebo-controlled study is evaluating farletuzumab in patients with FOLR1 expressing metastatic adenocarcinoma of lung.