MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas

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• 作者：Edoardo Missiaglia^a ; ¹ ; ² ; Chris J. Shepherd^a ; ¹ ; ³ ; Ewa Aladowicz^a ; ¹ ; David Olmos^a ; ⁴ ; Joanna Selfe^a ; Gaë ; lle Pierron^b ; Olivier Delattre^b ; Zoe Walters^a ; Janet Shipley^a ; ^{janet.shipley@icr.ac.uk}
• 关键词：MicroRNAs ; Next generation sequencing ; Co-expression modules ; Rhabdomyosarcoma ; Fusion protein
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：251-260
• 全文大小：2861 K
• 卷排序：385

文摘

RNAseq profiled miRNA expression in 64 rhabdomyosarcomas (RMS). MiRNA expression distinguished muscle and RMS on the basis of fusion gene status. Co-expression networks linked to function, clinical data and fusion gene status. Identified miRNAs, including miR-9-5p, altered by the PAX3-FOXO1 fusion protein. Demonstrated clinical and functional role for miR-9-5p in RMS.