Lidamycin regulates p53 expression by repressing Oct4 transcription
详细信息 查看全文
- 作者：Hong-Ying Zhena ; hyzhen@bjmu.edu.cn" class="auth_mail ; Juan Zhoub ; Hou-Nan Wuc ; Cheng Yaob ; Ting Zhanga ; Tong Wua ; Cheng-Shi Quand ; quancs@jlu.edu.cn" class="auth_mail ; Yu-Lin Lid ; ylli@jlu.edu.cn" class="auth_mail
- 关键词：Lidamycin ; Oct4 ; p53 ; Transcriptional activation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2 May 2014
- 年：2014
- 卷：447
- 期：2
- 页码：224-230
- 全文大小：1308 K
文摘
- •
We found that lidamycin (LDM) up-regulates tumor suppressor gene p53 expression by repressing Oct4 transcription.
- •
Suppression of Oct4 expression leads to activation of p53 by low-dose LDM.
- •
Knockdown Oct4 by siRNA results in p53 activation.
- •
Ectopical expression of Oct4 blocks p53 activation by low-dose LDM.
- •
Oct4 is downregulated by low-dose LDM through LDP directly binding to Oct4 promoter.