GATA3-driven expression of miR-503 inhibits prostate cancer progression by repressing ZNF217 expression
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- 作者：Xingkang Jiang ; Yue Chen ; E. Du ; Kuo Yang ; Zhihong Zhang ; Shiyong Qi ; yongshiqi@126.com" class="auth_mail" title="E-mail the corresponding author ; Yong Xu ; yongxu2012@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PCa ; prostate cancer ; EMT ; epithelial-mesenchymal transition ; qRT-PCR ; reverse transcription and quantitative real-time PCR analysis ; miRNA-503 ; mircoRNA-503 ; ChIP ; chromatin imunoprecipitation
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1216-1224
- 全文大小：1371 K
文摘
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Downregulated expression of miR-503 predicts poor prognosis in prostate cancer patients.
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Overexpression of miR-503 suppresses the growth of prostate cancer cells in vitro and in vivo.
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miR-503 inhibits ZNF217 expression to promote PCa progression.
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Aberrant expression of GATA3 mediates PCa progression by targeting miR-503/ZNF217.