NMDA receptor antagonism by repetitive MK801 administration induces schizophrenia-like structural changes in the rat brain as revealed by voxel-based morphometry and diffusion tensor imaging
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- 作者：H. Wua ; b ; &dagger ; ; X. Wangb ; &dagger ; ; Y. Gaob ; &dagger ; ; F. Linb ; T. Songa ; b ; Y. Zoua ; b ; L. Xub ; H. Leia ; b ; leihao@wipm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; cc ; corpus callosum ; DA ; axial diffusivity ; DG ; dentate gyrus ; DR ; radial diffusivity ; DTI ; diffusion tensor imaging ; ec ; external capsule ; FA ; fractional anisotropy ; FDR ; false discovery rate ; FOV ; field of view ; FWHM ; full width at half maximum ; GM ; gray matter ; HE ; hematoxylin and eosin ; M1 ; primary motor cortex ; MAM ; methylazoxymethanol acetate ; MBP ; myelin basic protein ; MD ; mean diffusivity ; MRI ; magnetic resonance imaging ; NeuN ; neuronal nuclei ; NMDAR ; N-methy
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：221-233
- 全文大小：2955 K
文摘
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Chronic MK801 treatment induces brain structural changes resembling those in schizophrenia.
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MK801-induced atrophy in the cortex and hippocampus is accompanied by neuronal degeneration.
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Widespread losses of parvalbumin positive cells observed after chronic MK801 treatment.
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Chronic MK801 treatment induces atrophy and diffusion abnormalities in the corpus callosum.