Extracorporeal Life Support for Refractory Cardiac Arrest from Accidental Hypothermia: A 10-Year Experience in Edinburgh

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• 作者：Maziar Khorsandi ; MRCS^&lowast ; ; ; Scott Dougherty ; MRCP^&dagger ; ; Neil Young ; FRCA^&Dagger ; ; Dean Kerslake ; FRCEM^§ ; ; Vincenzo Giordano ; MD^&lowast ; ; Robert Lendrum ; FRCA^&lowast ; ; William Walker ; FRCS^&lowast ; ; Vipin Zamvar ; FRCS^&lowast ; ; Ivan Yim ; MRCS^&lowast ; ; Renzo Pessotto ; FRCS^&lowast ;
• 关键词：extracorporeal membrane oxygenation ; heart arrest ; hypothermia
• 刊名：The Journal of Emergency Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：52
• 期：2
• 页码：160-168
• 全文大小：176 K
• 卷排序：52

文摘

Cardiac arrest caused by accidental hypothermia is a rare phenomenon with a significant mortality rate if untreated. The consensus is that these patients should be rewarmed with extracorporeal life support (ECLS) with the potential for excellent survival and neurologic outcomes. However, given the lack of robust data and clinical trials, the optimal management of such patients remains elusive.ObjectiveIn this single-center study, we looked at the outcomes of all adult patients undergoing salvage ECLS for cardiac arrest caused by accidental hypothermia over a 10-year period from June 2006 to June 2016.MethodsThese data were obtained from the Royal Infirmary of Edinburgh cardiothoracic surgery database. The patients' hard copy case notes, TrakCare (InterSystems Corp, Cambridge, MA), picture archiving and communications system (PACS), and WardWatcher databases were used to cross-check the accuracy of the acquired data.ResultsEleven patients met the inclusion criteria. The etiology of hypothermia was exposure to cold air (64%) and cold water immersion (36%). Two (18%) were treated with extracorporeal membrane oxygenation and the rest with cardiopulmonary bypass. The mean age was 51 years (range 32–73), and the mean core body temperature on admission was 20.6°C (range <18–24°C). The overall survival rate to hospital discharge was 72%, with 75% of survivors having no chronic neurologic impairment.ConclusionOur case series shows the remarkable salvageability of patients suffering prolonged cardiac arrest caused by accidental hypothermia, particularly in the absence of asphyxia, trauma, or severe hyperkalemia. ECLS is a safe and effective rewarming treatment and should be used to aggressively manage this patient group.