On the relationship between cellular and hemodynamic properties of the human brain cortex throughout adult lifespan
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- 作者：Yue Zhaoa ; Jie Wenb ; Anne H. Crossc ; Dmitriy A. Yablonskiyb ; yablonskiyd@mir.wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：GEPCI ; Gradient Echo Plural Contrast Imaging ; R2t⁎ ; tissue specific R2* ; Th ; the cortical thickness ; SR2t⁎ ; the product of the median R2t⁎ and the cortical thickness ; OEF ; oxygen extraction fraction ; dCBV ; deoxygenated cerebral blood volume ; Cdeoxy ; the concentration of deoxyhemoglobin ; VSF ; voxel spread function
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：417-429
- 全文大小：1703 K
文摘
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Transverse relaxation of MRI signal is separated in tissue (R2t⁎) and BOLD contributions.
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We hypothesize that R2t⁎ can serve as a biomarker of the cortical cellular packing density.
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Cortical regions with lower R2t⁎ are thicker and have lower oxygen extraction fraction (OEF).
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R2t⁎ grows with age in most cortical regions while OEF remains constant.
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Age-related increase in cortical R2t⁎ reflects increases in the cellular packing density.