Excess Cdt1 inhibits nascent strand elongation by repressing the progression of replication forks in Xenopus egg extracts
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- 作者：Yuta Nakazakia ; Takashi Tsuyamab ; Masayuki Sekic ; Mikiko Takahashia ; Takemi Enomotod ; Shusuke Tadaa ; b ; s.tada@phar.toho-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cdt1 ; DNA replication ; MCM helicase ; Xenopus egg extracts
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：470
- 期：2
- 页码：405-410
- 全文大小：1175 K
文摘
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Cdt1 induced accumulation of short DNA in reinitiation dependent manner.
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Inhibition of strand elongation by Cdt1 was independent of reinitiation.
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Replication forks were presumably suppressed by Cdt1.