Inflammatory Bowel Disease in African American Children Compared With Other Racial/Ethnic Groups in a Multicenter Registry

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• 作者：Jolanda M. White^?/sup> ; Siobhá ; n O'Connor^&Dagger ; ; Harland S. Winter^§ ; ; Melvin B. Heyman^?/sup> ; Barbara S. Kirschner^¶ ; ; George D. Ferry^# ; Stanley A. Cohen^?? ; Robert N. Baldassano^&Dagger ; &Dagger ; ; Terry Smith^§ ; § ; ; Traci Clemons^¡Î¡Î ; Benjamin D. Gold^?/sup> ; ^{ben_gold@oz.ped.emory.edu}
• 关键词：AA ; African American ; Alb ; albumin ; CD ; Crohn's disease ; 95 % CI ; 95 % confidence interval ; EIMCs ; extraintestinal manifestations and complications ; ESR ; erythrocyte sedimentation rate ; Hgb ; hemoglobin ; IBD ; inflammatory bowel disease ; IC ; indeterminate col
• 刊名：Clinical Gastroenterology and Hepatology
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：6
• 期：12
• 页码：1361-1369
• 全文大小：622 K

文摘

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Background & Aims

Few epidemiologic investigations characterize inflammatory bowel disease (IBD) in non-Caucasian children. Our study compared IBD characteristics between African Americans and non¨CAfrican Americans enrolled in a multicenter pediatric IBD registry with endoscopic- and pathology-based diagnosis.

Methods

The study retrieved data entered from January 2000 to October 2003 on children 1 to 17 years old, inclusive, followed by a consortium of academic and community US pediatric gastroenterology practices. Analyses examined racial/ethnic differences by comparing the proportions of African Americans and non¨CAfrican Americans in the following categories: each diagnostic disease classification (any IBD, Crohn's disease, ulcerative colitis, indeterminate colitis); age group (<6 y, 6?2 y, or >12 y) at diagnosis or symptom onset; presence of extraintestinal manifestations, Z-scores for height and weight, immunomodulatory therapy, anatomic disease location, and abnormal hemoglobin, albumin, or sedimentation rate at diagnosis.

Results

A total of 1406 patients had complete data, 138 (10 % ) of whom were African American. African Americans more often were older than 12 years of age at diagnosis (52 % vs 37 % ; odds ratio [OR], 1.82; 95 % confidence interval [95 % CI], 1.28?.59) and symptom onset (46 % vs 30 % ; OR, 1.99; 95 % CI, 1.40?.84); had Crohn's disease (78 % vs 59 % ; OR, 2.36; 95 % CI, 1.56?.58); and had a low hemoglobin level at diagnosis (39 % vs 17 % ; OR, 3.15; 95 % CI, 1.92?.17).

Conclusions

IBD in African American children and adolescents presents more commonly with Crohn's disease and at older ages compared with non¨CAfrican Americans. Racial/ethnic differences in the epidemiology of IBD, particularly Crohn's disease, among American youths require further investigation.