Hypothermia followed by rapid rewarming exacerbates ischemia-induced brain injury and augments inflammatory response in rats
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- 作者：Shu-Zhen Zhua ; b ; Yong Gua ; Zhou Wua ; Ya-Fang Hua ; Su-Yue Pana ; pansuyue82@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypothermia ; Rapid rewarming ; Ischemic stroke ; Blood&ndash ; brain barrier ; Inflammatory response
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：20 May 2016
- 年：2016
- 卷：474
- 期：1
- 页码：175-181
- 全文大小：1978 K
文摘
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Hypothermia followed by rapid rewarming (HTRR) increased Longa score and neurological deficit score.
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HTRR augmented the neuronal loss and the elevation of plasma NSE level in stroke model.
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HTRR increased the extravasation of Evans blue dye, enhanced MMP9 release and decreased tight junction proteins.
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HTRR increased the levels of cytokines, while minocycline reduced inflammation and improved neurological outcome.