Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets

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• 作者：Adam J. Dobson¹ ; Marina Ezcurra¹ ; Charlotte E. Flanagan¹ ; ³ ; Adam C. Summerfield¹ ; ⁴ ; Matthew D.W. Piper² ; David Gems¹ ; Nazif Alic¹ ; ⁵ ; ^{n.alic@ucl.ac.uk}
• 关键词：aging ; forkhead box O ; nutritional programming of lifespan ; Drosophila ; diet ; transcriptional regulation
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：299-306
• 全文大小：1915 K
• 卷排序：18

文摘

A high-sugar diet in early life programs Drosophila lifespan High sugar inactivates dFOXO, altering mRNA levels of chromatin modifiers dfoxo is required for long-term transcriptional changes in response to high sugar dfoxo and daf-16 are required for programming of lifespan by high-sugar diets