文摘
We studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions As a consequence of AChE inhibition, ACh neurotransmitters are being accumulated in over stimulated nicotinic and muscarinic receptors. With isolated diaphragm and ileum, we examined the down regulation of nicotinic and muscarinic receptor function through EFS technique. The results of our research could be useful in forensic diagnostics of organophosphate poisoning.