Contact Lens-induced Limbal Stem Cell Deficiency

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• 作者：Jennifer Rossen ; MD¹ ; Alec Amram ; MD¹ ; Behrad Milani ; MD¹ ; Dongwook Park ; MD¹ ; Jennifer Harthan ; OD ; FAAO² ; Charlotte Joslin ; OD ; PhD¹ ; Timothy McMahon ; OD ; FAAO¹ ; Ali Djalilian ; MD¹ ; ^{adjalili@uic.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：corneal conjunctivalization ; contact lens ; limbal stem cell deficiency ; limbal stem cells
• 刊名：The Ocular Surface
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：14
• 期：4
• 页码：419-434
• 全文大小：2414 K

文摘

Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.