Low incidence but poor prognosis of complicated coeliac disease: A retrospective multicentre study

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• 作者：Federico Biagi ; Paolo Gobbi ; Aless ; ra Marchese ; Edoardo Borsotti ; Fabiana Zingone ; Carolina Ciacci ; Umberto Volta ; Giacomo Caio ; Antonio Carroccio ; Giuseppe Ambrosiano ; Pasquale Mansueto ; Gino R. Corazza
• 关键词：Celiac disease/epidemiology ; Gluten ; Incidence ; Prognosis ; Risk assessment
• 刊名：Digestive and Liver Disease
• 出版年：March, 2014
• 年：2014
• 卷：46
• 期：3
• 页码：227-230
• 全文大小：721 K

文摘

Background

Coeliac disease is a chronic enteropathy characterized by an increased mortality caused by its complications, mainly refractory coeliac disease, small bowel carcinoma and abdominal lymphoma. Aim of the study was to study the epidemiology of complications in patients with coeliac disease.

Methods

Retrospective multicenter case-control study based on collection of clinical and laboratory data. The incidence of complicated coeliac disease was studied among coeliac patients directly diagnosed in four Italian centres. Patients referred to these centres after a diagnosis of coeliac disease and/or complicated coeliac disease in other hospitals were therefore excluded.

Results

Between 1/1999 and 10/2011, 1840 adult coeliac patients were followed up for 7364.3 person-years. Fourteen developed complications. Since five patients died, at the end of the observation period (10/2011), the prevalence of complicated coeliac disease was 9/1835 (1/204, 0.49%, 95% CI 0.2-0.9%). The annual incidence of complicated coeliac disease in the study period was 14/7364 (0.2%, 95% CI 0.1-0.31%). Although complications tend to occur soon after the diagnosis of coeliac disease, Kaplan-Meier curve analysis showed that they can actually occur at any time after the diagnosis of coeliac disease.

Conclusions

Complications of coeliac disease in our cohort were quite rare, though characterised by a very high mortality.