Local pH monitoring of small cluster of cells using a fiber-optic dual-core micro-probe

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• 作者：Sisi Chen^a ; ^cAuthor Vitae ; Qingbo Yang^a ; ^cAuthor Vitae ; Hai Xiao^b ; ^cAuthor Vitae ; Honglan Shi^a ; ^cAuthor Vitae ; Yinfa Ma^a ; ^c ; ^{yinfa@mst.edu}Author Vitae
• 关键词：pH micro-probe ; Fiber-optic sensor ; Cell heterogeneity ; Local/niche environment sensing ; Organic modified silicates (OrMoSils) ; TiO2 nanoparticles (NPs) cytotoxicity
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：31 March 2017
• 年：2017
• 卷：241
• 期：Complete
• 页码：398-405
• 全文大小：2959 K
• 卷排序：241

文摘

A miniaturized micro-probe was fabricated for monitoring the pHs in a niche cellular environment. Novel designed dual-core double-fiber configuration efficiently enhanced S/N ratio. Fast probe fabrication through a gravitational-stretching system and OrMoSil dip-coating technique. Acquire pH resolution of 0.035 ± 0.005 pH units within a biological relevant range of 6.20–7.92. Detecting early onset of cell deterioration induced by TiO2 nanoparticles on A549 cells.