Trypanosoma cruzi
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- 作者：Leony Cristina Caetano ; Fabricia Helena Santello ; Marina Del Vecchio Filipin ; Vâ ; nia Brazã ; o ; Luana Naiara Caetano ; Miriam Paula Alonso Toldo ; Jerri C. Caldeira ; José ; Cló ; vis do Prado
- 关键词：Trypanosoma cruzi ; Chronic phase ; DHEA ; Nitric oxide ; Splenocytes proliferation ; Interleukin-12
- 刊名：Veterinary Parasitology
- 出版年：2009
- 出版时间：7 July 2009
- 年：2009
- 卷：163
- 期：1-2
- 页码：27-32
- 全文大小：386 K
文摘
Dehydroepiandrosterone (DHEA) has long been considered as a precursor for many steroid hormones. It also enhances the immune responses against a wide range of viral, bacterial, and parasitic pathogens. The aims of this work were to evaluate the influences of exogenous DHEA treatment on Wistar rats infected with the Y strain of Trypanosoma cruzi during the acute and its influence on the chronic phase of infection. Animals were subcutaneous treated with 40 mg/kg body weight/day of DHEA. DHEA treatment promoted increased lymphoproliferative responses as well as enhanced concentrations of NO and IL-12. So, we point in the direction that our results validate the utility of the use of DHEA as an alternative therapy candidate against T. cruzi.