Country specific predictions of the cost-effectiveness of malaria vaccine RTS,S/AS01 in endemic Africa

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• 作者：Katya Galactionova^a ; ^b ; ^{e.galactionova@unibas.ch} ; Fabrizio Tediosi^a ; ^b ; Flavia Camponovo^a ; ^b ; Thomas A. Smith^a ; ^b ; Peter W. Gething^c ; Melissa A. Penny^a ; ^b
• 关键词：RTS ; S ; Malaria vaccine ; Cost-effectiveness ; Modelling and simulation
• 刊名：Vaccine
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：35
• 期：1
• 页码：53-60
• 全文大小：1198 K
• 卷排序：35

文摘

RTS,S has the potential to substantially reduce malaria burden in children in endemic Africa. Adding RTS,S to routine malaria control is potentially highly cost-effective. At PfPR2–10 > 10% predicted cost-effectiveness averages $136 per DALY averted. Under conservative assumptions predicted cost-effectiveness of RTS,S is, at most, doubled. Differences in country epidemiology and healthcare delivery result in substantial variation in predicted impact.