Rabies virus inactivates cofilin to facilitate viral budding and release
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- 作者：Jie Zana ; Shu-Ting Ana ; Kai-Kun Moa ; Jian-Wei Zhoua ; Juan Liua ; Hai-Long Wanga ; Yan Yana ; Min Liaoa ; liaomin4545@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ji-Yong Zhoua ; b
- 关键词：Rabies virus ; Viral budding ; Cytochalasin D ; Actin filaments ; Cofilin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：1045-1050
- 全文大小：1958 K
文摘
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RABV M protein-mediated virion budding depends on intact actin filaments.
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RABV infection inactivates cofilin to facilitate actin polymerization for RABV budding and release.
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Cofilin knock-down reduces viral release and detains viral budding vesicles in the cytoplasm.