CTRP6 inhibits fibrogenesis in TGF-β1-stimulated human dermal fibroblasts
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- 作者：Rong-hui Fana ; fan_ronghuixa@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiu-mei Zhua ; Yao-wen Suna ; Hui-zi Pengb ; Hang-li Wua ; Wen-jie Gaoa
- 关键词：C1q/tumor necrosis factor-related protein 6 (CTRP6) ; Skin fibrosis ; Dermal fibroblast ; Extracellular matrix (ECM)
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：8 July 2016
- 年：2016
- 卷：475
- 期：4
- 页码：356-360
- 全文大小：1021 K
文摘
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CTRP6 expression was decreased in scar tissues and TGF-β1-treated dermal fibroblasts.
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CTRP6 inhibits TGF-β1-induced the proliferation of dermal fibroblasts.
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CTRP6 inhibits expression of collagen type I and α-SMA.
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CTRP6 inhibits the activation of TGF-β1/Smad3 signaling pathway in dermal fibroblasts.