Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors
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- 作者：Chuang Xiaoa ; b ; Wu Liana ; c ; Lutan Zhoua ; b ; Na Gaoa ; b ; Li Xua ; b ; Jun Chena ; c ; Mingyi Wua ; mingyiwu_tju@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Wenlie Pengc ; pengwl@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jinhua Zhaoa ; zhao.jinhua@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：FG ; fucosylated glycosaminoglycan ; dFG ; depolymerized fucosylated glycosaminoglycan ; UFH ; unfractionated heparin ; LMWH ; low molecular weight heparin ; FXase ; factor Xase ; AT ; antithrombin ; FIIa ; thrombin ; FXa ; factor Xa ; FIXa ; factor IXa ; BLI ; biolayer interferometry ; HCII ; heparin cofactor II ; FVIII ; factor VIII ; Mw ; molecular weight ; Fpx ; fondaparinux ; FXIa ; factor XIa ; k1 ; pseudo-first order rate constant ; k2 ; second-order rate constant
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：59-68
- 全文大小：4770 K
文摘
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dFG-3 has much weaker catalysis activity of coagulation protease inhibition by AT compared with heparin.
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dFG-3 may not have allosteric activation effect on AT.
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dFG-3 binds to factor IXa with much higher affinity than heparin.
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Fucose side chains and carboxyl groups of dFG-3 may be required for its high affinity binding with factor IXa.