Higher blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations correlate with lower olfactory scores in essential tremor

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• 作者：Elan D. Louis ; Eileen Rios ; Kathryn M. Pellegrino ; Wendy Jiang ; Pam Factor-Litvak ; Wei Zheng
• 关键词：Essential tremor ; β ; -Carboline alkaloid ; Harmane ; Cerebellum ; Epidemiology ; Olfaction
• 刊名：Neurotoxicology
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：29
• 期：3
• 页码：460-465
• 全文大小：274 K

文摘

Harmane (1-methyl-9H-pyrido[3,4-b]indole), a neurotoxin, may be an environmental risk factor for essential tremor (ET). Harmane and related chemicals are toxic to the cerebellum. Whether it is through this mechanism (cerebellar toxicity) that harmane leads to ET is unknown. Impaired olfaction may be a feature of cerebellar disease.