Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
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- 作者：Bing Wanga ; 1 ; Ming-zhi Zhaoa ; 1 ; Nai-peng Cuia ; Dan-dan Linb ; An-yi Zhangb ; Yan Qinb ; Cai-yun Liua ; Wei-tao Yana ; Jian-hong Shib ; shijianhong1980@126.com" class="auth_mail" title="E-mail the corresponding author ; Bao-ping Chena ; cbp1962@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：KLF4 ; Krü ; ppel-like factor 4 ; iPSC ; induced pluripotent stem cell ; EMT ; epithelial&ndash ; mesenchymal transition ; FBS ; fetal bovine serum ; SNK ; Student&ndash ; Newman&ndash ; Keuls ; TNF-α ; tumor necrosis factor-α ; FACS ; fluorescence-activated cell sorting
- 刊名：FEBS Open Bio
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：147-154
- 全文大小：2060 K
文摘
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Krüppel-like factor 4 (KLF4) was downregulated in breast cancer tissues.
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KLF4 was upregulated in TNF-α–stimulated SK-BR-3 breast cancer cells.
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KLF4 inhibited proliferation and promoted apoptosis in breast cancer cells.
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40">Overexpression of KLF4 suppressed SK-BR-3 cell tumorigenicity in vivo.