Binge ethanol exposure increases the Krüppel-like factor 11-monoamine oxidase (MAO) pathway in rats: Examining the use of MAO inhibitors to prevent ethanol-induced brain injury
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- 作者：Jeremy W. Duncana ; b ; Xiao Zhanga ; b ; Niping Wangb ; Shakevia Johnsonb ; Sharonda Harrisb ; Chinelo Udemgbab ; Xiao-Ming Oub ; Moussa B. Youdimd ; Craig A. Stockmeierb ; Jun Ming Wanga ; b ; c ; jwang@umc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Binge ethanol ; Rats ; Kruppel-like factor 11 (KLF11) ; Transcription factor ; Monoamine oxidase (MAO) ; Neurotoxicity ; Protein oxidation ; BDNF ; Caspase-3
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：329-340
- 全文大小：1336 K
文摘
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The Krüppel-like factor 11-monoamine oxidase (KLF11-MAO) pathway is activated by binge ethanol exposure.
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Monoamine oxidase inhibitors (MAOIs) demonstrate neuroprotection by preventing binge ethanol-induced changes.
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Binge ethanol enhances markers of cell death/dysfunction such as caspase-3 and protein oxidation.