The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

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• 作者：Tsung-Ping Su¹ ; ^{TSU@intra.nida.nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Tzu-Chieh Su¹ ; Yoki Nakamura¹ ; Shang-Yi Tsai¹
• 关键词：sigma-1 receptor ; pluripotent modulator ; diseases
• 刊名：Trends in Pharmacological Sciences
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：37
• 期：4
• 页码：262-278
• 全文大小：2654 K

文摘

The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM), an interface between ER and mitochondria. In addition to being able to translocate to the plasma membrane (PM) to interact with ion channels and other receptors, Sig-1R also occurs at the nuclear envelope, where it recruits chromatin-remodeling factors to affect the transcription of genes. Sig-1Rs have also been reported to interact with other membranous or soluble proteins at other loci, including the cytosol, and to be involved in several central nervous system (CNS) diseases. Here, we propose that Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in living systems.