Synthesis and factorial design applied to a novel chitosan/sodium polyphosphate nanoparticles via ionotropic gelation as an RGD delivery system

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• 作者：Charlene Priscila Kiilll^a ; ^{char_kiill@yahoo.com.br} ; Hernane da Silva Barud^b ; Sí ; lvia Helena Santagneli^c ; Sidney José ; Lima Ribeiro^c ; Amé ; lia M. Silva^d ; Agnieszka Tercjak^e ; Junkal Gutierrez^e ; Andressa Maria Pironi^b ; Maria Palmira Daflon Gremiã ; o^a
• 关键词：Chitosan ; Nanoparticles ; Graham&rsquo ; s salt ; Ionic gelation ; Experimental factorial design ; cRGDfV
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：1695-1702
• 全文大小：2120 K
• 卷排序：157

文摘

This works shows how to obtain chitosan nanoparticles with sodium polyphosphate. Chitosan/polyphosphate nanoparticles were optimized using a 32 factorial design. RGD-loaded chitosan/polyphosphate nanoparticles were not cytotoxic in Caco-2 cells.