Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation
详细信息 查看全文
- 作者：Hui Gyu Parka ; Kumar S.D. Kothapallia ; ksk25@cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Woo Jung Parkb ; Christian DeAlliea ; Lei Liua ; Allison Lianga ; Peter Lawrencea ; J. Thomas Brennaa ; jtb4@cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PUFA ; polyunsaturated fatty acids ; MUFA ; monounsaturated fatty acid ; FADS ; Fatty acid desaturase ; SCD ; Stearoyl CoA desaturase ; FASN ; fatty acid synthase ; HUFA ; highly unsaturated fatty acids ; FAME ; Fatty acid methyl esters ; GC-CACI-MS/MS ; gas chromatography covalent adduct chemical ionization tandem mass spectrometry ; PC ; Phosphatidylcholine ; PE ; phosphatidylethanolamine ; PL ; phospholipids ; EI ; electronic impact ; ADA ; American Diabetes Association ; LCPUFA ; long chain PUFA ; EPA ; eicosapentaenoic
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1861
- 期：2
- 页码：91-97
- 全文大小：996 K
文摘
- •
In mammals the desaturation of saturated and polyunsaturated fatty acids (PUFA) is almost exclusively considered separately: the FADS genes apply to PUFA and the SCD apply to saturates
- •
Palmitic acid is the only exception, being a substrate for both SCD (16:0➔16:1n-7) and FADS2 (16:0➔16:1n-10)
- •
Competition experiments shows excess of 16:0 suppresses endogenous eicosanoid and docosanoid precursor synthesis by competing for FADS2 mediated desaturation with essential PUFA
- •
Metabolic conditions that induce local excess of 16:0 such as excess carbohydrate intake can inhibit synthesis of PUFA precursors for membrane synthesis and alter signaling precursors