Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy
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- 作者：Baoshang Zhoua ; Bing Fenga ; Zhexue Qinb ; Youguang Zhaoc ; Yu Chena ; Zhengmin Shia ; Yi Gonga ; Jing Zhanga ; Fahuan Yuana ; yuanfh023@126.com" class="auth_mail" title="E-mail the corresponding author ; Jiao Mua ; mujiaotmmu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Farnesoid X receptor ; Visfatin ; Diabetic nephropathy ; Mesangial cell
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：419
- 期：Complete
- 页码：72-82
- 全文大小：2194 K
文摘
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FXR activation downregulates visfatin expression in high glucose induced HMCs.
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FXR activation suppresses inflammatory responses and proliferation via inhibiting visfatin in high glucose induced HMCs.
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FXR activation suppresses TGF-β/Smad and ECM expression via inhibiting visfatin in high glucose induced HMCs.
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FXR activation suppresses visfatin transcription activity.
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FXR agonist reduces visfatin expression and ameliorates diabetic nephropathy in vivo.