Gastric stability and oral bioavailability of colistin sulfate in pigs challenged or not with Escherichia coli O149: F4 (K88)
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- 作者：Mohamed Rhoumaa ; b ; c ; Francis Beaudryd ; William Thé ; riaulta ; b ; c ; Nadia Bergerona ; b ; c ; Sylvette Laurent-Lewandowskia ; b ; c ; John Morris Fairbrotherb ; e ; Ann Letelliera ; b ; c ; d ; ann.letellier@umontreal.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：AUC ; area under the curve ; CS ; colistin sulfate ; ETEC ; enterotoxigenic E. coli ; IU ; international unit ; MIC ; minimum inhibitory concentration ; MRGN ; multi-resistant gram-negative ; PWD ; post-weaning diarrhea
- 刊名：Research in Veterinary Science
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：102
- 期：Complete
- 页码：173-181
- 全文大小：726 K
文摘
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We determine the in vitro gastric stability of colistin sulfate (CS).
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We determine the impact of CS gastric transit on antimicrobial activity.
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CS gastric transit is characterized by the formation of degradation products.
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CS degradation products have a greater antimicrobial activity compared with CS.
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Oral challenge of pigs by ETEC O149: F4 did not increase CS intestinal absorption.