Extended-spectrum cephalosporin (ESC)-resistant E. coli isolates from diseased pigs from 1997 to 2012 in Canada were examined.
ESC-resistant E. coli were mostly blaCMY-2-positive; blaCTX-M emerged in 2011.
ESC resistance associated with several clones that circulate between and persist on farms.
ESC-resistant E. coli possess one or more plasmids, including IncFIB, IncI1, IncA/C and IncFIC.
Presence of Inc plasmids was associated with pathotypes.