Classical Hodgkin lymphoma and its differential diagnoses

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• 作者：Falko Fend
• 关键词：classical Hodgkin lymphoma ; immunohistochemistry ; lymphoma classification ; nodular lymphocyte predominant Hodgkin lymphoma
• 刊名：Diagnostic Histopathology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：21
• 期：10
• 页码：400-407
• 全文大小：4207 K

文摘

Classical Hodgkin lymphoma (CHL) is a unique type of B-cell lymphoma defined by the presence of characteristic neoplastic cells, termed Hodgkin- and Reed-Sternberg cells, in an exuberant inflammatory background. CHL constitutes 15–20% of malignant lymphomas. Modern treatment modalities are able to cure the majority of patients. Despite the presence of clonal immunoglobulin gene rearrangements, the tumour cells lack a B-cell-specific expression program and show a phenotype devoid of most B-cell antigens, with CD30 and CD15 as characteristic markers. Although most cases of CHL can be diagnosed readily by morphology and a limited panel of immunohistochemical markers, a variety of malignant lymphomas and reactive conditions can imitate CHL, and true borderline cases with features intermediate between CHL and large B-cell lymphoma exist. This review summarizes the diagnostic criteria and relevant biological features of CHL and describes the most important differential diagnoses, including lymphocyte predominant Hodgkin lymphoma.