A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins
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- 作者：Giorgio Cozzaa ; giorgio.cozza@unipd.it" class="auth_mail" title="E-mail the corresponding author ; Mauro Salvia ; Sourav Banerjeec ; Elena Tibaldib ; Vincent S. Tagliabraccic ; Jack E. Dixonc ; Lorenzo A. Pinnaa ; lorenzo.pinna@unipd.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fam20C ; Family with Sequence Similarity 20 ; Member C ; G-CK ; Golgi-Casein Kinase or Genuine Casein Kinase ; DMP-4 ; Dentin Matrix Protein-4 ; OPN ; Osteopontin ; BMP15 ; Bone Morphogenetic Protein 15 ; IGFBP ; Insulin-like Growth Factor-Binding Protein ; FGF23 ; Fibroblast Growth Factor 23 ; SPT ; Serine Palmitoyltransferase ; STT ; Signal Transduction Therapy ; MS ; Multiple Sclerosis ; DLU ; Digital Line Units ; DMSO ; Dimethyl Sulfoxide
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：1854
- 期：10
- 页码：1718-1726
- 全文大小：975 K
文摘
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We demonstrate that sphingosine upregulates Fam20C activity.
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Sphingosine protects Fam20C against thermal inactivation.
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Blockage of sphingosine biosynthesis inactivates endogenous Fam20C.
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Fingolimod, an immunosuppressive drug, is an activator of Fam20C.
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Sphingosine and fingolimod significantly up-regulate Fam20C T268M defective mutant.