Targeting the inflammasome in rheumatic diseases

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• 作者：Sara S. McCoy^a ; Jasmine Stannard^a ; ^b ; J. Michelle Kahlenberg^a ; ^{mkahlenb@med.umich.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AIM2 ; Absent in Melanoma 2 ; AOSD ; adult-onset Still's disease ; AS ; ankylosing spondylitis ; ASC ; apoptosis-associated speck-like protein containing a caspase recruitment domain ; CAPS ; cryopyrin-associated periodic syndrome ; CARD ; caspase-recruitment domain ; CPPD ; calcium pyrophosphate dehydrate ; FA ; fatty acids ; FMF ; familial Mediterranean fever ; HIDS ; hyperimmunoglobulinemia D syndrome ; IL ; interleukin ; IL-1RA ; IL-1 receptor antagonist ; MSU ; monosodium urate ; NFκB ; nuclear factor κB ; NLR ; nod-li
• 刊名：Translational Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：167
• 期：1
• 页码：125-137
• 全文大小：744 K

文摘

Activation of the inflammasome, a protein complex responsible for many cellular functions, including the activation of the proinflammatory cytokines interleukin (IL)-1β and IL-18, has been identified as a key participant in many rheumatic diseases including autoimmune, inflammatory, and autoinflammatory syndromes. This review will discuss the recent advances in understanding the role of this complex in various rheumatic diseases. Furthermore, it will focus on available therapies, which directly and indirectly target the inflammasome and its downstream cytokines to quiet inflammation and possibly dampen autoimmune processes.