CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma
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- 作者：M. Bettia ; A. Aspesia ; A. Biasia ; E. Casaloneb ; c ; D. Ferranted ; P. Ogliarae ; L.C. Gironif ; R. Giorgionef ; P. Farinellif ; F. Grossog ; R. Libenerh ; S. Rosatoi ; D. Turchettij ; A. Maffè ; k ; C. Casadiol ; V. Ascolim ; C. Dianzanin ; E. Colombof ; E. Piccolinio ; M. Pavesip ; S. Miccolij ; D. Mirabelliq ; r ; C. Braccoe ; L. Righis ; R. Boldorinit ; M. Papottiu ; G. Matullob ; c ; C. Magnanid ; r ; B. Pasinib ; e ; 1 ; I. Dianzania ; r ; 1 ; irma.dianzani@med.uniupo.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：378
- 期：2
- 页码：120-130
- 全文大小：2380 K
文摘
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Melanoma and mesothelioma show a statistically significant co-occurrence in the general population.
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Inherited melanoma and mesothelioma predisposition is shown by individual with germline mutations in BAP1.
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We report a patient with mesothelioma who carried a germline mutation in CDKN2A, a gene involved in familial melanoma.
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This paper suggests that CDKN2A and possibly other genes may also predispose to both these tumors.
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It also suggests that mesothelioma and melanoma may share common stepwise carcinogenic pathways.