MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome

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• 作者：Yolanda Cá ; mara¹ ; ³ ; ⁴ ; Jorge Asin-Cayuela⁵ ; Chan  ; Bae Park⁷ ; Metodi  ; D. Metodiev⁸ ; Yonghong Shi¹ ; ⁶ ; Benedetta Ruzzenente⁸ ; Christian Kukat⁸ ; Bianca Habermann⁸ ; Rolf Wibom¹ ; Kjell Hultenby¹ ; Thomas Franz⁸ ; Hediye Erdjument-Bromage⁹ ; Paul Tempst⁹ ; B.  ; Martin Hallberg² ; Claes  ; M. Gustafsson⁶ ; ^{claes.gustafsson@medkem.gu.se"" rel=""nofollow} ; Nils-Gö ; ran Larsson¹ ; ⁸ ; ^{larsson@age.mpg.de"" rel=""nofollow}
• 刊名：Cell Metabolism
• 出版年：2011
• 出版时间：4 May 2011
• 年：2011
• 卷：13
• 期：5
• 页码：527-539
• 全文大小：1307 K

文摘

Summary

Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria.