JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region
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- 作者：Izaura Maria Vieira Cayres-Vallinoto ; ivallinoto@ufpa.br" class="auth_mail" title="E-mail the corresponding author ; Antonio Carlos Rosá ; rio Vallinoto ; Giselle Priscila dos Anjos Pena ; Vâ ; nia Nakauth Azevedo ; Luiz Fernando Almeida Machado ; Marluí ; sa de Oliveira Guimarã ; es Ishak ; Ricardo Ishak
- 关键词：JCV ; HIV-1 ; Co-infection ; Brazilian Amazon region
- 刊名：The Brazilian Journal of Infectious Diseases
- 出版年：2016
- 出版时间：July-August 2016
- 年：2016
- 卷：20
- 期：4
- 页码：360-364
- 全文大小：800 K
文摘
JC virus (JCV) is a member of the Polyomaviridae family and is associated to a severe disease known as progressive multifocal leukoencephalopathy, PML, which is gradually increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence of JCV among HIV-1 carriers including their types and molecular subtypes and the possible association with disease. Urine samples from 66 HIV-1 infected subjects were investigated for the presence of the virus by amplifying VP1 (215 bp) and IG (610 bp) regions using the polymerase chain reaction. JCV was detected in 32% of the samples. The results confirmed the occurrence of type B (subtype Af2); in addition, another polyomavirus, BKV, was also detected in 1.5% of samples of the HIV-1 infected subjects. Apparently, there was no significant difference between mono- (HIV-1 only) and co-infected (HIV-1/JCV) subjects regarding their TCD4+/TCD8+ lymphocyte counts or HIV-1 plasma viral load. Self admitted seizures, hearing and visual loses were not significantly different between the two groups.