Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B
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- 作者：Sheng-Li Zhu shenglizhu@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Li Wang liwang2010@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhong-Ying Cao caozhongying@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jun Wang wangjun2028@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ming-Zhen Jing jingmingzhen@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhang-Chuan Xia xiazhangchuan@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fang Ao 87310026@qq.com" class="auth_mail" title="E-mail the corresponding author ; Lin-Bai Ye linbaiye@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shi Liu ; liushi_liushi@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ying Zhu ; yingzhu@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP4F12 ; Hepatitis C virus ; Viral replication
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：26 February 2016
- 年：2016
- 卷：471
- 期：1
- 页码：95-102
- 全文大小：1635 K
文摘
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HCV infection induces CYP4F12 expression.
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NF-κB/P50 and SREBP1 are involved in the induction of CYP4F12 expression.
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CYP4F12 interacts with HCV NS5B, leading to the enhancement of HCV replication.