A ratiometric fluorescence probe for monitoring cyanide ion in live cells
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- 作者：Jianbin Chaoa ; chao@sxu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Zhiqing Lia ; bAuthor Vitae ; Yongbin ZhangaAuthor Vitae ; Fangjun HuoaAuthor Vitae ; Caixia YincAuthor Vitae ; Hongbo TongbAuthor Vitae ; Yuhong Liua ; bAuthor Vitae
- 关键词：Ratiometric fluorescence ; Cyanide-sensing ; Nucleophilic addition ; Detection limit ; Bioimaging
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：192-199
- 全文大小：2196 K
文摘
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A ratiometric fluorescent probe (Probe) is facilely synthesized via the ethylene bridging of N-ethylcarbazole-3-formaldehyde and 1,1,2-trimethyl-3-ethyl-1H-benz[e]indolium iodide.
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It is a useful fluorescent probe for monitoring cyanide ion at very low concentrations (1–2 μM), quantitatively.
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The detection limit of probe for CN− is found to be 0.23 μM.
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It exhibits a large Stokes shift, good selectivity, sensitivity and stability.
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Fluorescent CN− imaging in living cells by this probe is further successfully applied.