ID 134 - Transcranial magnetic stimulation in medication overuse headache: A new approach?

详细信息    查看全文

• 作者：F. Monti ; A. Granato ; M. Semenic ; J. Fantini ; P. Manganotti
• 刊名：Clinical Neurophysiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：127
• 期：3
• 页码：e119-e120
• 全文大小：43 K

文摘

To evaluate the efficacy of high-frequency rTMS in medication overuse headache (MOH).

Methods

A eight-month prospective, single-blind, randomized, placebo-controlled trial on patients with MOH consecutively presenting in our Headache Centre was performed. Patients were randomized into rTMS or sham-TMS group. Treatment consisted of 10 consecutively TMS sessions delivered on left dorsolateral prefrontal cortex, each session being 10 trains of 2-s duration, separated by 30-s pause, 20 Hz frequency, 100% motor threshold intensity. Demographic information, MIDAS score, headache days (HD), hours of headache (HH), and symptomatic drugs (SD) in the 3 months before (T0), and in the 3 months after stimulation (T1) were analyzed using SPSS 14.0.

Results

We enrolled 14 patients (12 F, 2 M; mean age 45 ± 10), 7 patients underwent rTMS and 7 sham-TMS. In T1, we found a significant reduction of all analyzed variables both in rTMS and in sham-TMS group. Higher improvement was found in rTMS group in HD (46% vs 36%), HH (50% vs 32%), and in MIDAS score (60% vs 43%). SD likewise reduced in both rTMS and sham-TMS group (60% vs 61%).

Conclusions

Our preliminary data suggest that high-frequency rTMS is slightly superior to sham in treating medication overuse headache.