文摘
Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of PXR. Acetylated DCA and CA enhance PXR target genes expression. Dehydrogenation or acetylation of DCA, CA, lithocholic (LCA) or chenodeoxycholic (CDCA) do not lead to increased affinity to FXR or VDR. Acetylated DCA and CA were not found in bile.